Can we validate a clinical score to predict the risk of severe infection in patients with systemic lupus erythematosus? A longitudinal retrospective study in a British Cohort
Identifieur interne : 000975 ( Main/Exploration ); précédent : 000974; suivant : 000976Can we validate a clinical score to predict the risk of severe infection in patients with systemic lupus erythematosus? A longitudinal retrospective study in a British Cohort
Auteurs : Beatriz Tejera Segura [Royaume-Uni] ; I Igo Rua-Figueroa [Espagne] ; Jose Maria Pego-Reigosa [Espagne] ; Victor Del Campo [Espagne] ; Chris Wincup [Royaume-Uni] ; David Isenberg [Royaume-Uni] ; Anisur Rahman [Royaume-Uni]Source :
- BMJ Open [ 2044-6055 ] ; 2019.
Abstract
Severe infections are a major cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Our primary objective was to use data from a large Spanish cohort to develop a risk score for severe infection in SLE, the SLE Severe Infection Score (SLESIS) and to validate SLESIS in a separate cohort of 699 British patients.
Retrospective longitudinal study in a specialist tertiary care clinic in London, UK.
Patients fulfilling international classification criteria for SLE (n=209). This included 98 patients who had suffered severe infections (defined as infection leading to hospitalisation and/or death) and 111 randomly selected patients who had never suffered severe infections.
We retrospectively calculated SLESIS at diagnosis for all 209 patients. For the infection cases we also calculated SLESIS just prior to infection and compared it to SLESIS in 98 controls matched for disease duration. We carried out receiver operator characteristic (ROC) analysis to quantify predictive value of SLESIS for severe infection.
Median SLESIS (IQR) at diagnosis was higher in the infection group than in the control group (4.27 (3.18) vs 2.55 (3.79), p=0.0008). Median SLESIS prior to infection was higher than at diagnosis (6.64 vs 4.27, p<0.001). In ROC analysis, predictive value of SLESIS just before the infection (area under the curve (AUC)=0.79) was higher than that of SLESIS at diagnosis (AUC=0.63).
We validated the association of SLESIS with severe infection in an independent cohort. Calculation of SLESIS at each clinic visit may help in management of infection risk in patients with SLE. Prospective studies are needed to confirm these findings.
Url:
DOI: 10.1136/bmjopen-2018-028697
PubMed: 31203250
PubMed Central: 6589043
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000417
- to stream Pmc, to step Curation: 000417
- to stream Pmc, to step Checkpoint: 000911
- to stream Ncbi, to step Merge: 000706
- to stream Ncbi, to step Curation: 000706
- to stream Ncbi, to step Checkpoint: 000706
- to stream Main, to step Merge: 000975
- to stream Main, to step Curation: 000975
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Can we validate a clinical score to predict the risk of severe infection in patients with systemic lupus erythematosus? A longitudinal retrospective study in a British Cohort</title>
<author><name sortKey="Tejera Segura, Beatriz" sort="Tejera Segura, Beatriz" uniqKey="Tejera Segura B" first="Beatriz" last="Tejera Segura">Beatriz Tejera Segura</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="department">Centre for Rheumatology Research</institution>
,<institution>University College London</institution>
,<addr-line content-type="city">London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rua Figueroa, I Igo" sort="Rua Figueroa, I Igo" uniqKey="Rua Figueroa I" first="I Igo" last="Rua-Figueroa">I Igo Rua-Figueroa</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Rheumatology Department</institution>
,<institution>Doctor Negrín University Hospital of Gran Canaria</institution>
,<addr-line content-type="city">Las Palmas de Gran Canaria</addr-line>
,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>RELESSER Study Group</institution>
,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pego Reigosa, Jose Maria" sort="Pego Reigosa, Jose Maria" uniqKey="Pego Reigosa J" first="Jose Maria" last="Pego-Reigosa">Jose Maria Pego-Reigosa</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution content-type="department">Rheumatology Department</institution>
,<institution>University Hospital Vigo, IRIDIS Group, Instituto de Investigación Sanitaria Galicia Sur (IISGS)</institution>
,<addr-line content-type="city">Vigo</addr-line>
,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>RELESSER Study Group</institution>
,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Del Campo, Victor" sort="Del Campo, Victor" uniqKey="Del Campo V" first="Victor" last="Del Campo">Victor Del Campo</name>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution content-type="department">Preventive Medicine and Epidemiology Department</institution>
,<institution>University Hospital Vigo, IRIDIS Group, Instituto de Investigación Sanitaria Galicia Sur (IISGS)</institution>
,<addr-line content-type="city">Vigo</addr-line>
,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wincup, Chris" sort="Wincup, Chris" uniqKey="Wincup C" first="Chris" last="Wincup">Chris Wincup</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="department">Centre for Rheumatology Research</institution>
,<institution>University College London</institution>
,<addr-line content-type="city">London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Isenberg, David" sort="Isenberg, David" uniqKey="Isenberg D" first="David" last="Isenberg">David Isenberg</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="department">Centre for Rheumatology Research</institution>
,<institution>University College London</institution>
,<addr-line content-type="city">London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rahman, Anisur" sort="Rahman, Anisur" uniqKey="Rahman A" first="Anisur" last="Rahman">Anisur Rahman</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="department">Centre for Rheumatology Research</institution>
,<institution>University College London</institution>
,<addr-line content-type="city">London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">31203250</idno>
<idno type="pmc">6589043</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589043</idno>
<idno type="RBID">PMC:6589043</idno>
<idno type="doi">10.1136/bmjopen-2018-028697</idno>
<date when="2019">2019</date>
<idno type="wicri:Area/Pmc/Corpus">000417</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000417</idno>
<idno type="wicri:Area/Pmc/Curation">000417</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000417</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000911</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000911</idno>
<idno type="wicri:Area/Ncbi/Merge">000706</idno>
<idno type="wicri:Area/Ncbi/Curation">000706</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000706</idno>
<idno type="wicri:Area/Main/Merge">000975</idno>
<idno type="wicri:Area/Main/Curation">000975</idno>
<idno type="wicri:Area/Main/Exploration">000975</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Can we validate a clinical score to predict the risk of severe infection in patients with systemic lupus erythematosus? A longitudinal retrospective study in a British Cohort</title>
<author><name sortKey="Tejera Segura, Beatriz" sort="Tejera Segura, Beatriz" uniqKey="Tejera Segura B" first="Beatriz" last="Tejera Segura">Beatriz Tejera Segura</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="department">Centre for Rheumatology Research</institution>
,<institution>University College London</institution>
,<addr-line content-type="city">London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rua Figueroa, I Igo" sort="Rua Figueroa, I Igo" uniqKey="Rua Figueroa I" first="I Igo" last="Rua-Figueroa">I Igo Rua-Figueroa</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Rheumatology Department</institution>
,<institution>Doctor Negrín University Hospital of Gran Canaria</institution>
,<addr-line content-type="city">Las Palmas de Gran Canaria</addr-line>
,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>RELESSER Study Group</institution>
,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pego Reigosa, Jose Maria" sort="Pego Reigosa, Jose Maria" uniqKey="Pego Reigosa J" first="Jose Maria" last="Pego-Reigosa">Jose Maria Pego-Reigosa</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution content-type="department">Rheumatology Department</institution>
,<institution>University Hospital Vigo, IRIDIS Group, Instituto de Investigación Sanitaria Galicia Sur (IISGS)</institution>
,<addr-line content-type="city">Vigo</addr-line>
,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>RELESSER Study Group</institution>
,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Del Campo, Victor" sort="Del Campo, Victor" uniqKey="Del Campo V" first="Victor" last="Del Campo">Victor Del Campo</name>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution content-type="department">Preventive Medicine and Epidemiology Department</institution>
,<institution>University Hospital Vigo, IRIDIS Group, Instituto de Investigación Sanitaria Galicia Sur (IISGS)</institution>
,<addr-line content-type="city">Vigo</addr-line>
,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wincup, Chris" sort="Wincup, Chris" uniqKey="Wincup C" first="Chris" last="Wincup">Chris Wincup</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="department">Centre for Rheumatology Research</institution>
,<institution>University College London</institution>
,<addr-line content-type="city">London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Isenberg, David" sort="Isenberg, David" uniqKey="Isenberg D" first="David" last="Isenberg">David Isenberg</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="department">Centre for Rheumatology Research</institution>
,<institution>University College London</institution>
,<addr-line content-type="city">London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rahman, Anisur" sort="Rahman, Anisur" uniqKey="Rahman A" first="Anisur" last="Rahman">Anisur Rahman</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="department">Centre for Rheumatology Research</institution>
,<institution>University College London</institution>
,<addr-line content-type="city">London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">BMJ Open</title>
<idno type="eISSN">2044-6055</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Objective</title>
<p>Severe infections are a major cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Our primary objective was to use data from a large Spanish cohort to develop a risk score for severe infection in SLE, the SLE Severe Infection Score (SLESIS) and to validate SLESIS in a separate cohort of 699 British patients.</p>
</sec>
<sec><title>Design and setting</title>
<p>Retrospective longitudinal study in a specialist tertiary care clinic in London, UK.</p>
</sec>
<sec><title>Participants</title>
<p>Patients fulfilling international classification criteria for SLE (n=209). This included 98 patients who had suffered severe infections (defined as infection leading to hospitalisation and/or death) and 111 randomly selected patients who had never suffered severe infections.</p>
</sec>
<sec><title>Outcomes</title>
<p>We retrospectively calculated SLESIS at diagnosis for all 209 patients. For the infection cases we also calculated SLESIS just prior to infection and compared it to SLESIS in 98 controls matched for disease duration. We carried out receiver operator characteristic (ROC) analysis to quantify predictive value of SLESIS for severe infection.</p>
</sec>
<sec><title>Results</title>
<p>Median SLESIS (IQR) at diagnosis was higher in the infection group than in the control group (4.27 (3.18) vs 2.55 (3.79), p=0.0008). Median SLESIS prior to infection was higher than at diagnosis (6.64 vs 4.27, p<0.001). In ROC analysis, predictive value of SLESIS just before the infection (area under the curve (AUC)=0.79) was higher than that of SLESIS at diagnosis (AUC=0.63).</p>
</sec>
<sec><title>Conclusions</title>
<p>We validated the association of SLESIS with severe infection in an independent cohort. Calculation of SLESIS at each clinic visit may help in management of infection risk in patients with SLE. Prospective studies are needed to confirm these findings.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Iliopoulos, Ag" uniqKey="Iliopoulos A">AG Iliopoulos</name>
</author>
<author><name sortKey="Tsokos, Gc" uniqKey="Tsokos G">GC Tsokos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Goldblatt, F" uniqKey="Goldblatt F">F Goldblatt</name>
</author>
<author><name sortKey="Chambers, S" uniqKey="Chambers S">S Chambers</name>
</author>
<author><name sortKey="Rahman, A" uniqKey="Rahman A">A Rahman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cervera, R" uniqKey="Cervera R">R Cervera</name>
</author>
<author><name sortKey="Khamashta, Ma" uniqKey="Khamashta M">MA Khamashta</name>
</author>
<author><name sortKey="Font, J" uniqKey="Font J">J Font</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jacobsen, S" uniqKey="Jacobsen S">S Jacobsen</name>
</author>
<author><name sortKey="Petersen, J" uniqKey="Petersen J">J Petersen</name>
</author>
<author><name sortKey="Ullman, S" uniqKey="Ullman S">S Ullman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hernandez Cruz, B" uniqKey="Hernandez Cruz B">B Hernández-Cruz</name>
</author>
<author><name sortKey="Tapia, N" uniqKey="Tapia N">N Tapia</name>
</author>
<author><name sortKey="Villa Romero, Ar" uniqKey="Villa Romero A">AR Villa-Romero</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kang, I" uniqKey="Kang I">I Kang</name>
</author>
<author><name sortKey="Park, Sh" uniqKey="Park S">SH Park</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Molina, H" uniqKey="Molina H">H Molina</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garred, P" uniqKey="Garred P">P Garred</name>
</author>
<author><name sortKey="Voss, A" uniqKey="Voss A">A Voss</name>
</author>
<author><name sortKey="Madsen, Ho" uniqKey="Madsen H">HO Madsen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cuchacovich, R" uniqKey="Cuchacovich R">R Cuchacovich</name>
</author>
<author><name sortKey="Gedalia, A" uniqKey="Gedalia A">A Gedalia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ucar Angulo, E" uniqKey="Ucar Angulo E">E Ucar Angulo</name>
</author>
<author><name sortKey="Rivera Garcia, N" uniqKey="Rivera Garcia N">N Rivera García</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zandman Goddard, G" uniqKey="Zandman Goddard G">G Zandman-Goddard</name>
</author>
<author><name sortKey="Shoenfeld, Y" uniqKey="Shoenfeld Y">Y Shoenfeld</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fessler, Bj" uniqKey="Fessler B">BJ Fessler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Danza, A" uniqKey="Danza A">A Danza</name>
</author>
<author><name sortKey="Ruiz Irastorza, G" uniqKey="Ruiz Irastorza G">G Ruiz-Irastorza</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Falagas, Me" uniqKey="Falagas M">ME Falagas</name>
</author>
<author><name sortKey="Manta, Kg" uniqKey="Manta K">KG Manta</name>
</author>
<author><name sortKey="Betsi, Gi" uniqKey="Betsi G">GI Betsi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Edwards, Cj" uniqKey="Edwards C">CJ Edwards</name>
</author>
<author><name sortKey="Lian, Ty" uniqKey="Lian T">TY Lian</name>
</author>
<author><name sortKey="Badsha, H" uniqKey="Badsha H">H Badsha</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ward, Mm" uniqKey="Ward M">MM Ward</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rua Figueroa, I" uniqKey="Rua Figueroa I">Í Rúa-Figueroa</name>
</author>
<author><name sortKey="L Pez Longo, J" uniqKey="L Pez Longo J">J López-Longo</name>
</author>
<author><name sortKey="Galindo Izquierdo, M" uniqKey="Galindo Izquierdo M">M Galindo-Izquierdo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zink, A" uniqKey="Zink A">A Zink</name>
</author>
<author><name sortKey="Manger, B" uniqKey="Manger B">B Manger</name>
</author>
<author><name sortKey="Kaufmann, J" uniqKey="Kaufmann J">J Kaufmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rua Figueroa, I" uniqKey="Rua Figueroa I">I Rúa-Figueroa</name>
</author>
<author><name sortKey="L Pez Longo, Fj" uniqKey="L Pez Longo F">FJ López-Longo</name>
</author>
<author><name sortKey="Calvo Alen, J" uniqKey="Calvo Alen J">J Calvo-Alén</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pego Reigosa, Jm" uniqKey="Pego Reigosa J">JM Pego-Reigosa</name>
</author>
<author><name sortKey="Rua Figueroa, I" uniqKey="Rua Figueroa I">Í Rúa-Figueroa</name>
</author>
<author><name sortKey="L Pez Longo, Fj" uniqKey="L Pez Longo F">FJ López-Longo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Katz, Jd" uniqKey="Katz J">JD Katz</name>
</author>
<author><name sortKey="Senecal, Jl" uniqKey="Senecal J">JL Senecal</name>
</author>
<author><name sortKey="Rivest, C" uniqKey="Rivest C">C Rivest</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hochberg, Mc" uniqKey="Hochberg M">MC Hochberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cervera, R" uniqKey="Cervera R">R Cervera</name>
</author>
<author><name sortKey="Khamashta, Ma" uniqKey="Khamashta M">MA Khamashta</name>
</author>
<author><name sortKey="Font, J" uniqKey="Font J">J Font</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Crowson, Cs" uniqKey="Crowson C">CS Crowson</name>
</author>
<author><name sortKey="Hoganson, Dd" uniqKey="Hoganson D">DD Hoganson</name>
</author>
<author><name sortKey="Fitz Gibbon, Pd" uniqKey="Fitz Gibbon P">PD Fitz-Gibbon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beca, S" uniqKey="Beca S">S Beça</name>
</author>
<author><name sortKey="Rodriguez Pint, I" uniqKey="Rodriguez Pint I">I Rodríguez-Pintó</name>
</author>
<author><name sortKey="Alba, Ma" uniqKey="Alba M">MA Alba</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Goldblatt, F" uniqKey="Goldblatt F">F Goldblatt</name>
</author>
<author><name sortKey="Yuste, J" uniqKey="Yuste J">J Yuste</name>
</author>
<author><name sortKey="Isenberg, Da" uniqKey="Isenberg D">DA Isenberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Duffy, Kn" uniqKey="Duffy K">KN Duffy</name>
</author>
<author><name sortKey="Duffy, Cm" uniqKey="Duffy C">CM Duffy</name>
</author>
<author><name sortKey="Gladman, Dd" uniqKey="Gladman D">DD Gladman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Noel, V" uniqKey="Noel V">V Noël</name>
</author>
<author><name sortKey="Lortholary, O" uniqKey="Lortholary O">O Lortholary</name>
</author>
<author><name sortKey="Casassus, P" uniqKey="Casassus P">P Casassus</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ruiz Irastorza, G" uniqKey="Ruiz Irastorza G">G Ruiz-Irastorza</name>
</author>
<author><name sortKey="Olivares, N" uniqKey="Olivares N">N Olivares</name>
</author>
<author><name sortKey="Ruiz Arruza, I" uniqKey="Ruiz Arruza I">I Ruiz-Arruza</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pryor, Bd" uniqKey="Pryor B">BD Pryor</name>
</author>
<author><name sortKey="Bologna, Sg" uniqKey="Bologna S">SG Bologna</name>
</author>
<author><name sortKey="Kahl, Le" uniqKey="Kahl L">LE Kahl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gladman, Dd" uniqKey="Gladman D">DD Gladman</name>
</author>
<author><name sortKey="Hussain, F" uniqKey="Hussain F">F Hussain</name>
</author>
<author><name sortKey="Iba Ez, D" uniqKey="Iba Ez D">D Ibañez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sis, A" uniqKey="Sis A">A Sisó</name>
</author>
<author><name sortKey="Ramos Casals, M" uniqKey="Ramos Casals M">M Ramos-Casals</name>
</author>
<author><name sortKey="Bove, A" uniqKey="Bove A">A Bové</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bultink, Ie" uniqKey="Bultink I">IE Bultink</name>
</author>
<author><name sortKey="Hamann, D" uniqKey="Hamann D">D Hamann</name>
</author>
<author><name sortKey="Seelen, Ma" uniqKey="Seelen M">MA Seelen</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Espagne</li>
<li>Royaume-Uni</li>
</country>
</list>
<tree><country name="Royaume-Uni"><noRegion><name sortKey="Tejera Segura, Beatriz" sort="Tejera Segura, Beatriz" uniqKey="Tejera Segura B" first="Beatriz" last="Tejera Segura">Beatriz Tejera Segura</name>
</noRegion>
<name sortKey="Isenberg, David" sort="Isenberg, David" uniqKey="Isenberg D" first="David" last="Isenberg">David Isenberg</name>
<name sortKey="Rahman, Anisur" sort="Rahman, Anisur" uniqKey="Rahman A" first="Anisur" last="Rahman">Anisur Rahman</name>
<name sortKey="Wincup, Chris" sort="Wincup, Chris" uniqKey="Wincup C" first="Chris" last="Wincup">Chris Wincup</name>
</country>
<country name="Espagne"><noRegion><name sortKey="Rua Figueroa, I Igo" sort="Rua Figueroa, I Igo" uniqKey="Rua Figueroa I" first="I Igo" last="Rua-Figueroa">I Igo Rua-Figueroa</name>
</noRegion>
<name sortKey="Del Campo, Victor" sort="Del Campo, Victor" uniqKey="Del Campo V" first="Victor" last="Del Campo">Victor Del Campo</name>
<name sortKey="Pego Reigosa, Jose Maria" sort="Pego Reigosa, Jose Maria" uniqKey="Pego Reigosa J" first="Jose Maria" last="Pego-Reigosa">Jose Maria Pego-Reigosa</name>
<name sortKey="Pego Reigosa, Jose Maria" sort="Pego Reigosa, Jose Maria" uniqKey="Pego Reigosa J" first="Jose Maria" last="Pego-Reigosa">Jose Maria Pego-Reigosa</name>
<name sortKey="Rua Figueroa, I Igo" sort="Rua Figueroa, I Igo" uniqKey="Rua Figueroa I" first="I Igo" last="Rua-Figueroa">I Igo Rua-Figueroa</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000975 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000975 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:6589043 |texte= Can we validate a clinical score to predict the risk of severe infection in patients with systemic lupus erythematosus? A longitudinal retrospective study in a British Cohort }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31203250" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a ChloroquineV1
This area was generated with Dilib version V0.6.33. |